early-humira-levels-in-a-non-responder

Ask The ExpertCategory: Questionsearly-humira-levels-in-a-non-responder
Daniel Kraft asked 10 months ago

In a Crohn’s patient (young, otherwise healthy male) that has not responded to Humira after the first dose, is there any utility in checking a trough level prior to dose #2?
Thank you

1 Answers
Catherine Riley Staff answered 10 months ago

We are not aware of any robust evidence that measuring adalimumab levels two weeks after the first induction dose is informative. While it is an appealing idea to identify individuals with rapid clearance who might benefit from early dose escalation, there is not sufficient evidence to implement this strategy and/or know what drug level might be targeted at this time point.